{"id":6200,"date":"2025-02-25T10:40:08","date_gmt":"2025-02-25T09:40:08","guid":{"rendered":"https:\/\/uni-freiburg.de\/frias\/?p=6200"},"modified":"2025-04-30T13:38:25","modified_gmt":"2025-04-30T11:38:25","slug":"prof-dr-manfred-jung","status":"publish","type":"post","link":"https:\/\/uni-freiburg.de\/frias\/prof-dr-manfred-jung\/","title":{"rendered":"Prof. Dr.\u00a0Manfred\u00a0Jung"},"content":{"rendered":"\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-top is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<div class=\"wp-block-media-text is-stacked-on-mobile is-vertically-aligned-top\" style=\"grid-template-columns:40% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"676\" height=\"1024\" src=\"https:\/\/uni-freiburg.de\/frias\/wp-content\/uploads\/sites\/62\/Jung-Sandro-676x1024.jpg\" alt=\"Portrait of Manfred Jung\" class=\"wp-image-6205 size-full\" srcset=\"https:\/\/uni-freiburg.de\/frias\/wp-content\/uploads\/sites\/62\/Jung-Sandro-676x1024.jpg 676w, https:\/\/uni-freiburg.de\/frias\/wp-content\/uploads\/sites\/62\/Jung-Sandro-198x300.jpg 198w, https:\/\/uni-freiburg.de\/frias\/wp-content\/uploads\/sites\/62\/Jung-Sandro-768x1163.jpg 768w, https:\/\/uni-freiburg.de\/frias\/wp-content\/uploads\/sites\/62\/Jung-Sandro-1015x1536.jpg 1015w, https:\/\/uni-freiburg.de\/frias\/wp-content\/uploads\/sites\/62\/Jung-Sandro-1353x2048.jpg 1353w, https:\/\/uni-freiburg.de\/frias\/wp-content\/uploads\/sites\/62\/Jung-Sandro.jpg 1582w\" sizes=\"auto, (max-width: 676px) 100vw, 676px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p>University of Freiburg<br>Pharmaceutical and Medicinal Chemistry<br><br>Internal Senior Fellow<br>October 2016 &#8211; July 2017<br>Interdisciplinary Research Group<br>October 2011 &#8211; July 2012<\/p>\n\n\n\n<div class=\"is-layout-flex wp-block-ufr-buttons-is-layout-flex\">\n\t\n\n<div class=\"wp-block-ufr-button\"> \n\t<a href=\"https:\/\/www.pharmazie.uni-freiburg.de\/chemie\/german\/professoren\/akjunghp\/\"\n\t\ttarget=\"_blank\" rel=\"noopener noreferrer\"\t\taria-label=\"\"\n\t\tclass=\"\n\t\tbl-text-[1.125rem] bl-leading-[1.5625rem] bl-px-[26px] bl-py-[7px] bl-border-[2px] bl-gap-[8px] !bl-decoration-2 !bl-underline-offset-[5px] focus-visible:bl-outline-offset-[6px]\t\tbl-no-underline hover:bl-underline bl-font-medium\n\t\t\n\t\tfocus-visible:bl-outline-dotted focus-visible:bl-outline-2 bl-border-identity-black bl-text-identity-black\n\t   hover:bl-bg-identity-blue-80 hover:bl-border-identity-blue-80 hover:bl-text-pure-white\n\t   active:bl-bg-identity-blue active:bl-text-pure-white active:bl-border-identity-blue\n\t   !bl-outline-identity-black dark:bl-text-pure-white dark:!bl-border-pure-white\n\t\tdark:hover:bl-text-identity-black dark:hover:bl-bg-identity-yellow-40 dark:hover:!bl-border-identity-yellow-40\n\t\tdark:active:bl-text-identity-black dark:active:bl-bg-identity-yellow dark:active:!bl-border-identity-yellow\n\t\tdark:!bl-outline-pure-white\t\tbl-inline-flex bl-flex-row bl-items-center motion-safe:bl-transition-colors\n\t\tmotion-safe:bl-duration-[400ms] justify-center bl-hyphens-auto\n\t\t\">\n\t\t\t\t<span class=\"bl-inline-block\">\n\t\t\tWebsite\t\t<\/span>\n\t<\/a>\n<\/div>\n\n<\/div>\n\n\n\n\n<p>E-Mail: <a href=\"mailto:martin.bemmann@geschichte.uni-freiburg.de\"><\/a><a href=\"mailto:blaird@ku.edu\"><\/a><a href=\"mailto:johanna.pink@orient.uni-freiburg.de\"><\/a><a href=\"mailto:johanna.pink@orient.uni-freiburg.de\"><\/a><a href=\"mailto:manfred.jung@pharmazie.uni-freiburg.de\"><\/a><a href=\"mailto:manfred.jung@pharmazie.uni-freiburg.de\">manfred.jung@pharmazie.uni-freiburg.de<\/a><\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<div class=\"[&amp;amp;&amp;gt;*]:bl-relative last:[&amp;amp;&amp;gt;*.bl-absolute]:bl-absolute\n\t\t\t[&amp;amp;&amp;gt;*]:bl-z-20 last:[&amp;amp;&amp;gt;*]:bl-z-10 bl-relative bl-overflow-x-clip\n\t\t\t[.wp-block-ufr-section_&amp;amp;]:bl-overflow-x-visible\n\t\t\tbl-bg-identity-lightblue bl-text-identity-black dark:bl-bg-identity-lightblue dark:bl-text-identity-black bl-py-[24px]  align wp-block-ufr-section has-global-padding is-layout-constrained wp-block-ufr-section-is-layout-constrained\">\n\n\t\n\n<p>Last Update: 31.08.2017<\/p>\n\n\t<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h2 class=\"wp-block-heading\">Curriculum Vitae<\/h2>\n\n\n\n<p>Manfred&nbsp;Jung obtained his PhD on the synthesis of aromatic retinoids at the University of Marburg in 1993. From 1993 to 1994 he did a postdoc with T. Durst at the University of Ottawa (Canada). From 1994 to 2003 he was a group leader at the University of M\u00fcnster and obtained his habilitation in Pharmaceutical Chemistry in 2000. Since 2003 he is a Professor of Pharmaceutical Chemistry at the University of Freiburg. In 2010 he received an offer for a full professorship to the University of Mainz that he declined and he is a Full Professor in Freiburg since 2011. He is currently the Dean of the Faculty of Chemistry and Pharmacy. The topic of his research is Chemical Epigenetics with a major focus on histone modifying enzymes. His group is working on inhibitor synthesis, assay development and screening for inhibitors of reversible histone acetylation and methylation.<\/p>\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"bl-w-full wp-block-ufr-accordion\">\n\n\n<article class=\"ufr-accordion-container-wrapper\" data-accordion=\"animationDuration: 400; direction: vertical; collapsible: true; \">\n\t<div class=\"ufr-accordion-container-flex-wrapper \">\n\t\t\n\n<section\n\tid=\"Selected-Publications\"\n\tclass=\"ufr-accordion-item-section\n\tufr-accordion-item-section--vertical\">\n\t<div class=\"bl-group\/accordion-header ufr-accordion-item-header\n\t\t\t\"\n\trole=\"button\"\n\ttabindex=\"0\"\n\taria-label=\"Toggle accordion item: Selected Publications\"\n\taria-controls=\"Accordion Selected-Publications content\"\n\t>\n\t\t<div class=\"ufr-accordion-item-header-wrapper\n\t\t\t\t\t\">\n\t\t\t\t\t\t<h3 class=\"ufr-accordion-item-header-heading\n\t\t\t\tufr-accordion-item-header-heading--vertical\t\t\t\">\n\t\t\t\tSelected Publications\t\t\t<\/h3>\n\t\t<\/div>\n\t\t<span class=\"\n\t\t\tchevron-container\n\t\t\tufr-accordion-item-header-chevron-container\n\t\t\tufr-accordion-item-header-chevron-container--!numbered ufr-accordion-header-chevron-container--light-in-lightmode ufr-accordion-header-chevron-container--dark-in-darkmode \t\t\" aria-hidden=\"true\">\n\t\t\t<svg width=\"100%\" viewBox=\"0 0 35 50\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n\taria-label=\"chevron-right\" class=\"bl-h-[40px] md:bl-h-[40px] xl:bl-h-[100px] bl-rotate-90\" role=\"img\">\n\t<title>chevron-right<\/title>\n\t<path d=\"M5.00012 5L25.6062 25.0002L5.00012 45\" stroke=\"currentColor\" stroke-width=\"12\" \/>\n<\/svg>\n\t\t<\/span>\n\t<\/div>\n\t<div\n\t\tid=\"Accordion Selected-Publications content\"\n\t\tclass=\"ufr-accordion-item-body\n\t\t\tufr-accordion-item-body--vertical\t\t\"\n\t\t\t>\n\t\t\t\t<div\n\t\tclass=\"ufr-accordion-item-body-outer-content-wrapper\n\t\t\t\t\t\"\n\t\taria-hidden=\"true\"\n\t\t>\n\t\t\t<div class=\"is-layout-flow\n\t\t\t\t\t\t\t\">\n\t\t\t\t\n\n<ul class=\"wp-block-list\">\n<li>Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform. T. Wagner, H. Greschik, T. Burgahn, K. Schmidtkunz, A.\u2011K. Schott, J. McMillan, L. Baranauskien\u0117, Y. Xiong, O. Fedorov, J. Jin, U. Oppermann, D. Matulis, R. Sch\u00fcle, M. Jung;&nbsp;<strong>Nucl.&nbsp;<\/strong><strong>Acids Res.&nbsp;<\/strong>(2016)&nbsp;<em>doi:<\/em><em>10.1093\/nar\/gkw089<\/em>.<\/li>\n\n\n\n<li>Assembly of methylated LSD1 and CHD1 drives AR dependent transcription and translocation. E. Metzger, D. Willmann, J. McMillan, I. Forne, P. Metzger, S. Gerhardt, K. Petroll, A. von Maessenhausen, S. Urban, A.-K. Schott, A. Espejo, A. Eberlin, D.&nbsp; Wohlwend, K. M. Sch\u00fcle,<br>M. Schleicher, S. Perner, M. T. Bedford, M. Jung, J. Dengjel, R. Flaig, A. Imhof, O. Einsle,<br>R. Sch\u00fcle;&nbsp;<strong>Nat. Struct. Mol. Biol.<\/strong>&nbsp;23 (2016) 132-139.<\/li>\n\n\n\n<li>Structure-based Development of a Sirtuin 2 Affinity Probe. M. Schiedel, T. Rumpf, B. Karaman, A. Lehotzky, S. Gerhardt, J. Ov\u00e1di, W. Sippl, O. Einsle, M. Jung;&nbsp;<strong>Angew. Chem. Int. Ed.&nbsp;<\/strong>55 (2016) 2252-2256.<\/li>\n\n\n\n<li>Selective Sirt2-inhibition by ligand-induced rearrangement of the active site. T. Rumpf,<br>M. Schiedel, B. Karaman, C. Roessler, B. J. North, A. Lehotzky, J. Olah, K. I. Ladwein,<br>K. Schmidtkunz, M. Gajer, M. Pannek, C. Steegborn, D. A. Sinclair, S. Gerhardt, J. Ovadi,<br>M. Schutkowski, W. Sippl, O. Einsle, M. Jung,&nbsp;<strong>Nat. Commun.&nbsp;<\/strong>6 (2015) 6263.<\/li>\n\n\n\n<li>Synthesis and biological investigation of oxazole hydroxamates as highly selective histone deacetylase 6 (HDAC6) inhibitors. J. Senger, J. Melesina, M. Marek, C. Romier, I. Oehme,<br>O. Witt, W. Sippl, M. Jung;&nbsp;<strong>J. Med. Chem.<\/strong>&nbsp;59 (2016) 1545\u20131555.<a href=\"\"><\/a><\/li>\n<\/ul>\n\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/section>\n\n\n\n<section\n\tid=\"FRIAS-Project-2\"\n\tclass=\"ufr-accordion-item-section\n\tufr-accordion-item-section--vertical\">\n\t<div class=\"bl-group\/accordion-header ufr-accordion-item-header\n\t\t\t\"\n\trole=\"button\"\n\ttabindex=\"0\"\n\taria-label=\"Toggle accordion item: FRIAS Project\"\n\taria-controls=\"Accordion FRIAS-Project-2 content\"\n\t>\n\t\t<div class=\"ufr-accordion-item-header-wrapper\n\t\t\t\t\t\">\n\t\t\t\t\t\t<h3 class=\"ufr-accordion-item-header-heading\n\t\t\t\tufr-accordion-item-header-heading--vertical\t\t\t\">\n\t\t\t\tFRIAS Project\t\t\t<\/h3>\n\t\t<\/div>\n\t\t<span class=\"\n\t\t\tchevron-container\n\t\t\tufr-accordion-item-header-chevron-container\n\t\t\tufr-accordion-item-header-chevron-container--!numbered ufr-accordion-header-chevron-container--light-in-lightmode ufr-accordion-header-chevron-container--dark-in-darkmode \t\t\" aria-hidden=\"true\">\n\t\t\t<svg width=\"100%\" viewBox=\"0 0 35 50\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n\taria-label=\"chevron-right\" class=\"bl-h-[40px] md:bl-h-[40px] xl:bl-h-[100px] bl-rotate-90\" role=\"img\">\n\t<title>chevron-right<\/title>\n\t<path d=\"M5.00012 5L25.6062 25.0002L5.00012 45\" stroke=\"currentColor\" stroke-width=\"12\" \/>\n<\/svg>\n\t\t<\/span>\n\t<\/div>\n\t<div\n\t\tid=\"Accordion FRIAS-Project-2 content\"\n\t\tclass=\"ufr-accordion-item-body\n\t\t\tufr-accordion-item-body--vertical\t\t\"\n\t\t\t>\n\t\t\t\t<div\n\t\tclass=\"ufr-accordion-item-body-outer-content-wrapper\n\t\t\t\t\t\"\n\t\taria-hidden=\"true\"\n\t\t>\n\t\t\t<div class=\"is-layout-flow\n\t\t\t\t\t\t\t\">\n\t\t\t\t\n\n<h3 class=\"wp-block-heading\"><strong><strong>Chemical Epigenetics<\/strong><\/strong><\/h3>\n\n\n\n<p>Epigenetics is one of the major topics of modern biomedical research and is already a major focus in the Freiburg research landscape with international visibility. We will establish a Research Focus on Chemical Epigenetics that deals with epigenetic mechanisms on a molecular level using our combined expertise in synthetic organic and medicinal chemistry, structural biochemistry and bioinformatics to address this topic in a highly synergistic manner. The main scientific focus of our project will be acetyl and methyl lysine binding proteins, so called histone code readers. Structural analyses provide the basis for identification and optimization of new chemical ligands for these proteins in a rational, bioguided fashion. This will lead to new chemical tools that will allow dissecting cellular pathways involving these proteins as well as the analysis of their suitability as targets in drug discovery. The structural aim of this project is the preparation of a proposal for a structured PhD programme in Chemical Epigenetics with a strong international education perspective.<\/p>\n\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/section>\n\n\t<\/div>\n<\/article>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<div class=\"[&amp;amp;&amp;gt;*]:bl-relative last:[&amp;amp;&amp;gt;*.bl-absolute]:bl-absolute\n\t\t\t[&amp;amp;&amp;gt;*]:bl-z-20 last:[&amp;amp;&amp;gt;*]:bl-z-10 bl-relative bl-overflow-x-clip\n\t\t\t[.wp-block-ufr-section_&amp;amp;]:bl-overflow-x-visible\n\t\t\tbl-bg-transparent bl-text-inherit dark:bl-bg-transparent dark:bl-text-inherit  alignfull wp-block-ufr-section has-global-padding is-layout-constrained wp-block-ufr-section-is-layout-constrained\">\n\n\t\t\t\t<div class=\"bl-absolute bl-inset-0 bl-w-full bl-h-full bl-pointer-events-none bl-mt-0\">\n\t\t\t<div\n\t\t\tclass=\"bl-absolute bl-origin-center\n\t\t\t\tbl-w-96\t\t\t\tbl-top-[50%] -bl-translate-y-[50%] bl-left-[50%] -bl-translate-x-[50%]\t\t\t\t\">\n\t\t\t\t<svg\n\twidth=\"100%\"\n\tviewBox=\"0 0 64.5 64.5\"\n\tfill=\"none\"\n\txmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n\taria-label=\"\"\n\tclass=\"bl-relative bl-block dark:bl-hidden bl-w-full\"\n\trole=\"img\">\n\t<title><\/title>\n<linearGradient\n\tid=\"lYwo8sKIuF\"\n\tx1=\"50%\" y1=\"100%\"\n\tx2=\"50%\" y2=\"0%\">\n\t<stop\n\t\toffset=\"0%\"\n\t\tstop-color=\"#f5c2ed\"\n\t\tstop-opacity=\"1\" \/>\n\t<stop\n\t\toffset=\"100%\"\n\t\tstop-color=\"#f5c2ed\"\n\t\tstop-opacity=\"0\" \/>\n<\/linearGradient>\n\t<path\n\t\td=\"m32.25,64c17.53,0,31.75-14.21,31.75-31.75S49.78.5,32.25.5.5,14.71.5,32.25s14.21,31.75,31.75,31.75\"\n\t\tstroke-width=\"2px\"\n\t\tvector-effect=\"non-scaling-stroke\"\n\t\tfill=\"url(#lYwo8sKIuF)\" \/>\n<\/svg>\n<svg\n\twidth=\"100%\"\n\tviewBox=\"0 0 64.5 64.5\"\n\tfill=\"none\"\n\txmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n\taria-label=\"\"\n\tclass=\"bl-relative bl-hidden dark:bl-block bl-w-full\"\n\trole=\"img\">\n\t<title><\/title>\n<linearGradient\n\tid=\"HGPsJeDqhS\"\n\tx1=\"50%\" y1=\"100%\"\n\tx2=\"50%\" y2=\"0%\">\n\t<stop\n\t\toffset=\"0%\"\n\t\tstop-color=\"#000149\"\n\t\tstop-opacity=\"1\" \/>\n\t<stop\n\t\toffset=\"100%\"\n\t\tstop-color=\"#000149\"\n\t\tstop-opacity=\"0\" \/>\n<\/linearGradient>\n\t<path\n\t\td=\"m32.25,64c17.53,0,31.75-14.21,31.75-31.75S49.78.5,32.25.5.5,14.71.5,32.25s14.21,31.75,31.75,31.75\"\n\t\tstroke-width=\"2px\"\n\t\tvector-effect=\"non-scaling-stroke\"\n\t\tfill=\"url(#HGPsJeDqhS)\" \/>\n<\/svg>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:128px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>University of FreiburgPharmaceutical and Medicinal Chemistry Internal Senior FellowOctober 2016 &#8211; July 2017Interdisciplinary Research GroupOctober 2011 &#8211; July 2012 E-Mail: manfred.jung@pharmazie.uni-freiburg.de Curriculum Vitae Manfred&nbsp;Jung obtained his PhD on the synthesis of aromatic retinoids at the University of Marburg in 1993. From 1993 to 1994 he did a postdoc with T. Durst at the University of<\/p>\n","protected":false},"author":296,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_trash_the_other_posts":false,"editor_notices":[],"_show_in_pageentry_slider":true,"_pageentry_slider_title":"","footnotes":""},"categories":[283,53,165,26,31,366,42,40],"tags":[],"class_list":["post-6200","post","type-post","status-publish","format-standard","hentry","category-2011-12","category-2016-17","category-chemistry","category-fellow","category-germany","category-interdisciplinary-research-group","category-senior-fellowship-programme","category-university-of-freiburg"],"featured_image_url":null,"featured_image_alt":"","_links":{"self":[{"href":"https:\/\/uni-freiburg.de\/frias\/wp-json\/wp\/v2\/posts\/6200","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/uni-freiburg.de\/frias\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/uni-freiburg.de\/frias\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/uni-freiburg.de\/frias\/wp-json\/wp\/v2\/users\/296"}],"replies":[{"embeddable":true,"href":"https:\/\/uni-freiburg.de\/frias\/wp-json\/wp\/v2\/comments?post=6200"}],"version-history":[{"count":4,"href":"https:\/\/uni-freiburg.de\/frias\/wp-json\/wp\/v2\/posts\/6200\/revisions"}],"predecessor-version":[{"id":8342,"href":"https:\/\/uni-freiburg.de\/frias\/wp-json\/wp\/v2\/posts\/6200\/revisions\/8342"}],"wp:attachment":[{"href":"https:\/\/uni-freiburg.de\/frias\/wp-json\/wp\/v2\/media?parent=6200"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/uni-freiburg.de\/frias\/wp-json\/wp\/v2\/categories?post=6200"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/uni-freiburg.de\/frias\/wp-json\/wp\/v2\/tags?post=6200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}