{"id":879,"date":"2024-12-13T14:29:29","date_gmt":"2024-12-13T13:29:29","guid":{"rendered":"https:\/\/uni-freiburg.de\/med-biochemie\/?p=879"},"modified":"2026-03-02T12:46:04","modified_gmt":"2026-03-02T11:46:04","slug":"die-proteinkinase-dyrk1a-integriert-und-synchronisiert-die-mitochondriale-importmaschinerie","status":"publish","type":"post","link":"https:\/\/uni-freiburg.de\/med-biochemistry\/die-proteinkinase-dyrk1a-integriert-und-synchronisiert-die-mitochondriale-importmaschinerie\/","title":{"rendered":"Protein kinase DYRK1A identified as a central integrator and synchronizer of the mitochondrial import machinery"},"content":{"rendered":"\n

Mitochondrial proteins are synthesized in the cytosol and are imported into mitochondria, where they are involved in converting the energy contained in our food into the cell-usable energy form adenosine triphosphate (ATP).<\/strong><\/p>\n\n\n\n

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Network of mitochondria in human cells (green: mitochondria, blue: nucleus). Picture: Group Claudine Kraft, University of Freiburg<\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n

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In a recent study the groups of Chris Meisinger (A06) and Nora V\u00f6gtle (B04) found that the protein machinery responsible for the import is regulated by a signal integrator which ensures that the mitochondria receive the proteins required for the respective metabolic state. This particular signalling integrator is the protein kinase DYRK1A (dual-specificity tyrosine-phosphorylation-regulated kinase 1A), which the researchers had previously identified as an activator of the TOM70 import receptor.<\/p>\n\n\n\n

In further investigations, they were now able to show that the activity of DYRK1A regulates the availability of the other import receptors. This leads to a remodelling of the TOM complex and adaption of the import machinery to the acute metabolic situation.<\/p>\n\n\n\n

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Marada A., Walter C., Suhm T., Shankar S., Nandy A., Brummer T., Dhaouadi I., V\u00f6gtle FN., Meisinger C. (2024). DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring<\/strong>. In: Nature Communications. 15:5265. DOI: 10.1038\/s41467-024-49611-4.<\/p>\n\n\t<\/div>\n<\/div>\n\n\n\n

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Mitochondrial proteins are synthesized in the cytosol and are imported into mitochondria, where they are involved in converting the energy contained in our food into the cell-usable energy form adenosine triphosphate (ATP). Network of mitochondria in human cells (green: mitochondria, blue: nucleus). Picture: Group Claudine Kraft, University of Freiburg In a recent study the groups<\/p>\n","protected":false},"author":90,"featured_media":3030,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_trash_the_other_posts":false,"editor_notices":[],"_show_in_pageentry_slider":true,"_pageentry_slider_title":"","footnotes":""},"categories":[5],"tags":[19,16,20],"class_list":["post-879","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-newsbeitrag","tag-chris-meisinger","tag-claudine-kraft","tag-nora-vogtle"],"featured_image_url":"https:\/\/uni-freiburg.de\/med-biochemistry\/wp-content\/uploads\/sites\/335\/Eiweismolekule-in-Mitochondrien-erstmals-klar-zugeordnet.png","featured_image_alt":"","_links":{"self":[{"href":"https:\/\/uni-freiburg.de\/med-biochemistry\/wp-json\/wp\/v2\/posts\/879","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/uni-freiburg.de\/med-biochemistry\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/uni-freiburg.de\/med-biochemistry\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/uni-freiburg.de\/med-biochemistry\/wp-json\/wp\/v2\/users\/90"}],"replies":[{"embeddable":true,"href":"https:\/\/uni-freiburg.de\/med-biochemistry\/wp-json\/wp\/v2\/comments?post=879"}],"version-history":[{"count":3,"href":"https:\/\/uni-freiburg.de\/med-biochemistry\/wp-json\/wp\/v2\/posts\/879\/revisions"}],"predecessor-version":[{"id":3253,"href":"https:\/\/uni-freiburg.de\/med-biochemistry\/wp-json\/wp\/v2\/posts\/879\/revisions\/3253"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/uni-freiburg.de\/med-biochemistry\/wp-json\/wp\/v2\/media\/3030"}],"wp:attachment":[{"href":"https:\/\/uni-freiburg.de\/med-biochemistry\/wp-json\/wp\/v2\/media?parent=879"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/uni-freiburg.de\/med-biochemistry\/wp-json\/wp\/v2\/categories?post=879"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/uni-freiburg.de\/med-biochemistry\/wp-json\/wp\/v2\/tags?post=879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}