Prof. Dr. Susana Minguet
Focus of research
- The nano-organization of the plasma membrane in T and B lymphocytes
- Understanding T cells activation to develop translational and synthetic applications to improve T-cell immunotherapies against cancer
CV
- 2019 Associated researcher of the Cluster of Excellence CIBSS, Centre for Integrative Biological Signalling Studies
- 2018 Habilitation in Immunology; University of Freiburg
- 2017 Member of the Cluster of Excellence BIOSS, Centre for Biological Signalling Studies
- 2016 Member of the Center of Chronic Immunodeficiency (CCI)
- Since 2011 Group Leader in the Department of Immunology, University of Freiburg, Faculty of Biology (Freiburg, Germany)
- 2008–2011 Ramón & Cajal Fellow (Centro Nacional de Investigaciones Cardiovasculares Carlos III · CNIC (Madrid, Spain)
- 2003–2007 Postdoc, Max Planck-Institute for Immunobiology and Epigenetics (Freiburg, Germany)
- 1997–2002 PhD degree in Sciences (Biochemistry and Molecular Biology). Universidad Autónoma de Madrid (UAM) Spain
- 1992–1997 Degree in Chemical Sciences (Biochemistry and Molecular Biology). Universidad Autónoma de Madrid (UAM) Spain
Selected publications
- From TCR fundamental research to innovative chimeric antigen receptor design. Minguet S, Maus MV & Schamel W. Nat Rev Immunol. 2024. doi: 10.1038/s41577-024-01093-7
- Velasco Cárdenas RM, Brandl SM, Meléndez AV, Schlaak AE, Buschky A, Peters T, Beier F, Serrels B, Taromi S, Raute K, Hauri S, Gstaiger M, Lassmann S, Huppa JB, Boerries M, Andrieux G, Bengsch B, Schamel WW§, Minguet S§. Harnessing CD3 diversity to optimize CAR T cells. Nat Immunol. 2023 doi: 10.1038/s41590-023-01658-z. §Shared senior author
- Raute K, Strietz J, Parigiani MA, Andrieux G, Thomas OS, Kistner KM, Zintchenko M, Aichele P, Hofmann M, Zhou H, Weber W, Boerries M, Swamy M, Maurer J, Minguet, S. Breast Cancer Stem Cell-Derived Tumors Escape from γδ T-cell Immunosurveillance In Vivo by Modulating γδ T-cell Ligands. Cancer Immunol Res. 2023 doi: 10.1158/2326-6066.CIR-22-0296.
- Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function. Hartl FA, Beck-Garcìa E, Woessner NM, Flachsmann LJ, Cárdenas RMV, Brandl SM, Taromi S, Fiala GJ, Morath A, Mishra P, Yousefi OS, Zimmermann J, Hoefflin N, Köhn M, Wöhrl BM, Zeiser R, Schweimer K, Günther S, Schamel WW§, Minguet S§. Nat Immunol 2020 doi: 10.1038/s41590-020-0732-3. Highlighted in the cover page of the issue. §Shared senior author.
- Goetz, J.G*., S. Minguet*, I. Navarro-Lérida, J.J. Lazcano, R. Samaniego, E. Calvo, M. Tello, T. Osteso-Ibáñez, T. Pellinen, A. Echarri, A. Cerezo, A.J. P. Klein-Szanto, R. Garcia, P.J. Keely, P. Sánchez-Mateos, E. Cukierman, and M.A. Del Pozo. Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis. Cell 2011 doi: 10.1016/j.cell.2011.05.040. *Shared first authorship.