Prof. Dr. Pitter Huesgen

Focus of research

• Proteomics method development
• Protease substrate identifcation
• Proteolysis in cellular stress responses

CV

• Since 2023, W3 Professor for Biochemistry (Functional Proteomics), Faculty of Biology
• 2019–2023, W2 Professor for Protein Dynamics and Proteolysis at CECAD, Medical Faculty, University of Cologne
• 2014–2023, Team leader at the Central Institute for Engineering, Electronics and Analytics, Forschungszentrum Jülich
• 2008–2014, Postdoc at the Centre for Blood Research, University of British Columbia, Vancouver, Canada
• 2003–2007, PhD studies in plant biochemistry, University of Konstanz

Selected publications

• Barghahn S^#, Saridis G^#, Mantz M^#, Meyer U, Mellüh JC, Misas Villamil JC, Huesgen PF*, Doehlemann G* (2023) Combination of transcriptomic, proteomic and degradomic profiling reveals common and distinct patterns of pathogen-induced cell death in maize. The Plant Journal. 116:574-596. doi: 10.1111/tpj.1635
• Demir F*, Kizhakkedathu JN, Rinschen MM, Huesgen PF* (2021) MANTI: Automated Annotation of Protein N-Termini for Rapid Interpretation of N-Terminome Data Sets. Analytical Chemistry 93:5596-5605.
• Hofsetz E, Demir F, Szczepanowska K, Kukat A, Kizhakkedathu J, Trifunovic A*, Huesgen PF* (2020) The mouse heart mitochondria N terminome provides insights into ClpXP-mediated proteolysis Molecular and Cellular Proteomics 19:1330-1345.
• Weng SSH, Demir F, Ergin EK, Dirnberger S, Uzozie A, Tuscher D, Nierves L, Tsui J, Huesgen PF*, Lange PF* (2019) Sensitive determination of proteolytic proteoforms in limited microscale proteome samples. Molecular and Cellular Proteomics 18:2335-2347.
• Huesgen PF, Lange PF, Rogers LR, Solis N, Eckhard U, Kleifeld O, Gomis-Rüth XF, Overall CM (2015) LysargiNase mirrors trypsin for protein C-termini and methylation site identification. Nature Methods 12, 55-8.
  
  (^# shared first, * shared corresponding authors)