PD Dr. Daria Onichtchouk
Focus of research
- The mechanisms of zygotic genome activation.
- Cell specification in early zebrafish development
- Role of pioneer transcription factors in early embryonic development
CV
- Since 2013 Group leader, Department of Developmental Biology, Faculty of Biology, University of Freiburg
- 2015 Habilitation, Venia Legendi (teaching authorization) for the subject Developmental Biology of Animals, Faculty of Biology, University of Freiburg
- 2006–2012 Academic Councillor, Department of Developmental Biology (Prof. Driever), Faculty of Biology, University of Freiburg
- 2001–2006 Senior Scientist, DeveloGen AG, Göttingen
- 1999–2001 Postdoctoral researcher at the MPI for Biophysical Chemistry, Göttingen
- 1999 Doctorate (Dr. rer. nat.), Faculty of Mathematics and Natural Sciences, Ruprecht-Karls-University Heidelberg.
- 1995–1999 PhD student, DKFZ Heidelberg
- 1992–1995 Research Associate, Medical Research Center for Hematology RAS, Moscow, Russian Federation.
- 1989–1992 Parental leave
- 1982–1989 Studied biology, Dipl.-Biol., Lomonosov Moscow State University, Russian Federation
Selected publications
- Riesle AJ, Gao M, Rosenblatt M, Hermes J, Hass H, Gebhard A, Veil M, Grüning B, Timmer J*, Onichtchouk D*. Activator-blocker model of transcriptional regulation by pioneer-like factors. Nat Commun. 2023 Sep 14;14(1):5677. doi: 10.1038/s41467-023-41507-z.
- Gao M, Veil M, Rosenblatt M, Riesle AJ, Gebhard A, Hass H, Buryanova L, Yampolsky LY, Grüning B, Ulianov SV, Timmer J, Onichtchouk D*. Pluripotency factors determine gene expression repertoire at zygotic genome activation. Nat Commun. 2022 Feb 10;13(1):788. doi: 10.1038/s41467-022-28434-1.
- Veil M, Yampolsky LY, Grüning B, Onichtchouk D*. Pou5f3, SoxB1, and Nanog remodel chromatin on high nucleosome affinity regions at zygotic genome activation. Genome Res. 2019 Mar;29(3):383-395
- Marina Veil, Melanie Anna Schaechtle, Meijiang Gao, Viola Inéz Nora Kirner, Lenka Buryanova, Rachel Grethen, and Daria Onichtchouk*. Maternal Nanog is required for the zebrafish embryo architecture and for cell viability during gastrulation. Development. 2018 Jan 9;145(1).
- M. Leichsenring, J. Maes, R. Mössner, W. Driever*, D. Onichtchouk*. Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science. 2013 Aug 30;341(6149):1005-9.