Selected Publications
- Asymmetric synthesis of N-allylic indoles via regio- and enantioselective allylation of aryl hydrazines, Xu, K.; Gilles, T.; Breit, B. Nature Commun. 2015, DOI:10.1038/ncomms8616.
- Regio- and Enantioselective Synthesis of N-Substituted Pyrazoles by Rhodium-Catalyzed Asymmetric Addition to Allenes, Haydl, A. M.; Xu, K.; Breit, B. Angew. Chem. Int. Ed. 2015, 54, 7149–7153.
- Rhodium-Catalyzed Hydroformylation of 1,1-Disubstituted Allenes Employing the Self-Assembling 6-DPPon System, Köpfer, A.; Breit, B. Angew. Chem. Int. Ed. 2015, 54, 6913–6917.
- Enantioselective Redox-Neutral Rh-Catalyzed Coupling of Terminal Alkynes with Carboxylic Acids Towards Branched Allylic Esters, Koschker, P.; Kähny, M.; Breit, B. J. Am. Chem. Soc. 2015, 137, 3131–3137.
- Rhodium-Catalyzed Chemo-, Regio-, and Enantioselective Addition of 2-Pyridones to Terminal Allenes, Li, C.; Kähny, M.; Breit, B. Angew. Chem. Int. Ed. 2014, 53, 13780–13784.
FRIAS Project
Chemical Epigenetics
Epigenetics is one of the major topics of modern biomedical research and is already a major focus in the Freiburg research landscape with international visibility. We will establish a Research Focus on Chemical Epigenetics that deals with epigenetic mechanisms on a molecular level using our combined expertise in synthetic organic and medicinal chemistry, structural biochemistry and bioinformatics to address this topic in a highly synergistic manner. The main scientific focus of our project will be acetyl and methyl lysine binding proteins, so called histone code readers. Structural analyses provide the basis for identification and optimization of new chemical ligands for these proteins in a rational, bioguided fashion. This will lead to new chemical tools that will allow dissecting cellular pathways involving these proteins as well as the analysis of their suitability as targets in drug discovery. The structural aim of this project is the preparation of a proposal for a structured PhD programme in Chemical Epigenetics with a strong international education perspective.
Project 2008-2010
Man made soft matter requires environmentally benign techniques for construction and modification. As such the field of catalysis plays a major role, since catalysis provides a unique resource- and energy-saving way for building matter on a molecular defined level. Crucial to this goal is the development of new molecular catalysts and catalytic reactions that allow for efficient waste-free and highly selelctive chemical transformations. Towards this goal the expertise of the Krische group (new atom economic carbon carbon bond forming reactions) and Breit group (defined molecular catalyst based on self-assembly) will be combined.