Selected Publications
- Ailion M., Hannemann M., Dalton S., Pappas A.,Watanabe S., Hegermann J., Liu Q., Han H.-F., Gu M., Goulding M.Q., Sasidharan N., Schuske K., Hullett P., Eimer S., and Jorgensen E.M. (2014) Two Novel Rab2 Interactors Regulate Dense-core Vesicle Maturation. Neuron; 82(1):167-80.
- Kittelmann M., Liewald J.F., Hegermann J., Schultheis C., Brauner M., Steuer Costa W., Wabnig S., Eimer S.*, Gottschalk A.* (2013) In vivo synaptic recovery following optogenetic hyperstimulation. (*corresponding authors) PNAS; 110(32): E3007-3016.
- Sasidharan N., Sumakovic M., Hannemann M., Hegermann J., Liewald H., Olendrowitz C., Grant B.D., Rizzoli S.O., Gottschalk A. and Eimer S. (2012) Selective regulation of dense core vesicle release by a novel Rab cascade in Caenorhabditis elegans. PNAS; 109(46):18944-9.
- Hannemann M., Sasidharan N., HegermannJ., Koenig S. and Eimer S. (2012) TBC-8, a novel RAB-2 GAP involved in dense core vesicle maturation in C. elegans. PLoS Genetics; 8(5):e1002722.
- Witte K., Schuh A.L., Sarkeshik A., Hegermann J., Mayers J.R., Schwarze K., Yates III J.R., Eimer S., and Audhya A. (2011) Mechanisms by which TFG functions in protein secretion and oncogenesis. Nat. Cell Biol., 13(5):550-8.
FRIAS Project
Regulation of mitochondrial integrity by Rab GTPase mediated control of mitophagy.
Small GTPases of the Rab family are master-regulators of intracellular trafficking and sorting events between different membrane domains. Rab GTPases function thereby as molecular switches which recruit in their ON, GTP-bound, state a set of effector molecules that execute downstream events. In addition to their control of multiple steps during vesicular membrane transport, Rab GTPases also provide identity to intracellular membrane structures and organelles, facilitating directed transport. However, despite our basic knowledge about general Rab GTPase function, the mechanisms of Rab GTPase mediated crosstalk between different organelles to maintain cellular homeostasis is not well understood. Interestingly, through genetic screens in the nematode Caenorhabditis elegans we have identified the Rab GTPase GLO-1, which is involved in trafficking to the lysosome related organelle, to be required for mitochondrial integrity and function. Thus glo-1 mutants might be a good model system to understand lysosomal storage diseases.