Selected Publications
- Hartleben, B., Godel, M., Meyer-Schwesinger, C., Liu, S., Ulrich, T., Kobler, S., Wiech, T., Grahammer, F., Arnold, S.J., Lindenmeyer, M.T., Cohen, C.D., Pavenstadt, H., Kerjaschki, D., Mizushima, N., Shaw, A.S., Walz, G., and Huber, T.B. 2010. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest120:1084-1096.
- Godel, M., Hartleben, B., Herbach, N., Liu, S., Zschiedrich, S., Lu, S., Debreczeni-Mor, A., Lindenmeyer, M.T., Rastaldi, M.P., Hartleben, G., Wiech, T., Fornoni, A., Nelson, R.G., Kretzler, M., Wanke, R., Pavenstadt, H., Kerjaschki, D., Cohen, C.D., Hall, M.N., Ruegg, M.A., Inoki, K., Walz, G., and Huber, T.B. 2011. Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest121:2197-2209.
- Liu, S., Hartleben, B., Kretz, O., Wiech, T., Igarashi, P., Mizushima, N., Walz, G., and Huber, T.B. 2012. Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury. Autophagy 8:826-837.
- Grahammer, F., Haenisch, N., Steinhardt, F., Sander, L., Roerden, M., Arnold, F., Cordts, T., Wanner, N., Reichardt, W., Kerjaschki, D., Ruegg, M.A., Hall, M.N., Moulin, P., Busch, H., Boerries, M., Walz, G., Artunc, F., and Huber, T.B. 2014. mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci U S A.
- Godel, M., Grahammer, F., and Huber, T.B. 2015. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. N Engl J Med 372:1073.
FRIAS Project
Membrane Trafficking in Ageing and Disease.
Increasing age causes progressive deterioration of tissues and organs, leading to impaired tissue function, increased organismal vulnerability to infection, and death. Hence ageing is recognized as a prime disease factor. Improving health in the elderly will be crucial to deal with the enormous socio-economic challenges arising as a consequence of increased life expectancy. Membranes are at the center of cellular biology, compartmentalizing cells into functional distinct sub-compartments and constituting scaffolds for signal initiation and propagation. Hence, it is not surprising that deregulated membrane trafficking emerges also as key processes in ageing and disease. By combining model organisms, such as C.elegans and mouse, with mammalian cell culture, advanced molecular biology and protein biochemistry, and ‘omics’ approaches we aim at characterizing deregulated membrane trafficking in ageing and disease. This will allow a functional understanding of underlying biological processes which can be employed to design strategies promoting healthy ageing.