Publications

Here we highlight a selection of significant research contributions from the Signalling Factory & Robotics team.

2024

A New Silicon Phthalocyanine Dye Induces Pyroptosis in Prostate Cancer Cells during Photoimmunotherapy.
Wolf, I.; Storz, J.; Schultze-Seemann, S.; Esser, P. R.; Martin, S. F.; Lauw, S.; Fischer, P.; Peschers, M.; Melchinger, W.; Zeiser, R.; Gorka, O.; Groß, O.; Gratzke, C.; Brückner, R.; Wolf, P.
Bioactive Materials 2024, 41, 537–552. https://doi.org/10.1016/j.bioactmat.2024.07.025

Kidins220 Regulates the Development of B Cells Bearing the λ Light Chain.
Schaffer, A.-M.; Fiala, G. J.; Hils, M.; Natali, E.; Babrak, L.; Herr, L. A.; Romero-Mulero, M. C.; Cabezas-Wallscheid, N.; Rizzi, M.; Miho, E.; Schamel, W. W.; Minguet, S.
eLife 2024, 13, e83943. https://doi.org/10.7554/eLife.83943

Pectin Methylesterase Activity Is Required for RALF1 Peptide Signalling Output.
Rößling, A.-K.; Dünser, K.; Liu, C.; Lauw, S.; Rodriguez-Franco, M.; Kalmbach, L.; Barbez, E.; Kleine-Vehn, J.
eLife 2024, 13, RP96943. https://doi.org/10.7554/eLife.96943

Photoimmunotherapy of HER2-Expressing Breast Cancer Cells.
Klemenz, L.; Wolf, I.; Storz, J.; Schultze-Seemann, S.; Gratzke, C.; Lauw, S.; Brückner, R.; Wolf, P.
Cancer Genomics Proteomics 2024, 21 (4), 361–367. https://doi.org/10.21873/cgp.20453

Reprogramming of Human γδ T Cells by Expression of an Anti-CD19 TCR Fusion Construct (εTRuC) to Enhance Tumor Killing.
Juraske, C.; Krissmer, S. M.; Teuber, E. S.; Parigiani, M. A.; Strietz, J.; Wesch, D.; Kabelitz, D.; Minguet, S.; Schamel, W. W.
Journal of Leukocyte Biology 2024, 115 (2), 293–305. https://doi.org/10.1093/jleuko/qiad128

iNClusive: A Database Collecting Useful Information on Non-Canonical Amino Acids and Their Incorporation into Proteins for Easier Genetic Code Expansion Implementation.
Icking, L.-S.; Riedlberger, A. M.; Krause, F.; Widder, J.; Frederiksen, A. S.; Stockert, F.; Spädt, M.; Edel, N.; Armbruster, D.; Forlani, G.; Franchini, S.; Kaas, P.; Kırpat Konak, B. M.; Krier, F.; Lefebvre, M.; Mazraeh, D.; Ranniger, J.; Gerstenecker, J.; Gescher, P.; Voigt, K.; Salavei, P.; Gensch, N.; Di Ventura, B.; Öztürk, M. A
Nucleic Acids Research 2024, 52 (D1), D476–D482. https://doi.org/10.1093/nar/gkad1090

Antibody-Dye Conjugates Targeting EGFR and HER2 for the Photoimmunotherapy of Bladder Cancer.
Huber, F.; Wolf, I.; Storz, J.; Schultze-Seemann, S.; Lauw, S.; Klemenz, L.; Miernik, A.; Gratzke, C.; Brückner, R.; Wolf, P.
Anticancer Res2024, 44 (5), 1837–1844. https://doi.org/10.21873/anticanres.16985

OptoREACT: Optogenetic Receptor Activation on Nonengineered Human T Cells.
Armbruster, A.; Ehret, A. K.; Russ, M.; Idstein, V.; Klenzendorf, M.; Gaspar, D.; Juraske, C.; Yousefi, O. S.; Schamel, W. W.; Weber, W.; Hörner, M.
ACS Synth. Biol. 2024, 13 (3), 752–762. https://doi.org/10.1021/acssynbio.3c00518

2023

Dimeric Lectin Chimeras as Novel Candidates for Gb3-Mediated Transcytotic Drug Delivery through Cellular Barriers.
Xu, M.; Antonova, M.; Salavei, P.; Illek, K.; Meléndez, A. V.; Omidvar, R.; Thuenauer, R.; Makshakova, O.; Römer, W.
Pharmaceutics 2023, 15 (1), 225. https://doi.org/10.3390/pharmaceutics15010225

A Shiga Toxin B-Subunit-Based Lectibody Boosts T Cell Cytotoxicity towards Gb3-Positive Cancer Cells.
Tomisch, J.; Busse, V.; Rosato, F.; Makshakova, O.; Salavei, P.; Kittel, A.-S.; Gillon, E.; Lataster, L.; Imberty, A.; Meléndez, A.; Römer, W.
Cells 2023, 12 (14), 1896. https://doi.org/10.3390/cells12141896

Engineering of an Optogenetic T Cell Receptor Compatible with Fluorescence-Based Readouts.
Ehret, A. K.; Yousefi, O. S.; Schamel, W. W.
ACS Synth. Biol. 2023, 12 (10), 2857–2864. https://doi.org/10.1021/acssynbio.3c00429

A Photoreceptor‐Based Hydrogel with Red Light‐Responsive Reversible Sol‐Gel Transition as Transient Cellular Matrix.
Hörner, M.; Becker, J.; Bohnert, R.; Baños, M.; Jerez‐Longres, C.; Mühlhäuser, V.; Härrer, D.; Wong, T. W.; Meier, M.; Weber, W.
Adv Materials Technologies 2023, 8 (16), 2300195. https://doi.org/10.1002/admt.202300195

SPATA2 Restricts OTULIN-Dependent LUBAC Activity Independently of CYLD.
Griewahn, L.; Müller-Foxworth, M.; Peintner, L.; Wissler, M.; Weiss, M.; Brauns-Schubert, P.; Massoumi, R.; Borner, C.; Groß, O.; Yabal, M.; Charvet, C.; Maurer, U.
Cell Reports 2023, 42 (1), 111961. https://doi.org/10.1016/j.celrep.2022.111961

Clickable Shiga Toxin B Subunit for Drug Delivery in Cancer Therapy.
Danielewicz, N.; Rosato, F.; Tomisch, J.; Gräber, J.; Wiltschi, B.; Striedner, G.; Römer, W.; Mairhofer, J.
ACS Omega 2023, 8 (17), 15406–15421. https://doi.org/10.1021/acsomega.3c00667

Membrane Targeting with Palmitoylated Lysine Added to PP1‐disrupting Peptide Induces PP1‐independent Signaling.
Chojnacki, J. E.; Scheinost, L.; Wang, Y.; Köhn, M.
Journal of Peptide Science 2023, 29 (6), e3469. https://doi.org/10.1002/psc.3469

2022

Novel Lectin-Based Chimeric Antigen Receptors Target Gb3-Positive Tumour Cells.
Römer, W.; Meléndez, A. V.; Cárdenas, R. M.-H. V.; Lagies, S.; Siukstaite, L.; Thomas, O. S.; Weber, W.; Kammerer, B.; Minguet, S.
In Review April 27, 2022. https://doi.org/10.21203/rs.3.rs-1327761/v1

Pulling, Failing, and Adaptive Mechanotransduction of Macrophage Filopodia.
Michiels, R.; Gensch, N.; Erhard, B.; Rohrbach, A.
Biophysical Journal 2022, 121 (17), 3224–3241. https://doi.org/10.1016/j.bpj.2022.07.028

Krüppel-like Factor 7 Influences Translation and Pathways Involved in Ribosomal Biogenesis in Breast Cancer.
Lüchtenborg, A.-M.; Metzger, P.; Cosenza Contreras, M.; Oria, V.; Biniossek, M. L.; Lindner, F.; Fröhlich, K.; Malyi, A.; Erbes, T.; Gensch, N.; Maurer, J.; Thomsen, A.; Boerries, M.; Schilling, O.; Werner, M.; Bronsert, P.
Breast Cancer Res 2022, 24 (1), 65. https://doi.org/10.1186/s13058-022-01562-8

Mesenchymal-Endothelial Nexus in Breast Cancer Spheroids Induces Vasculogenesis and Local Invasion in a CAM Model.
Li, A.; Muenst, S.; Hoffman, J.; Starck, L.; Sarem, M.; Fischer, A.; Hutter, G.; Shastri, V. P.
Commun Biol 2022, 5 (1), 1303. https://doi.org/10.1038/s42003-022-04236-5

100 Hz ROCS Microscopy Correlated with Fluorescence Reveals Cellular Dynamics on Different Spatiotemporal Scales.
Jünger, F.; Ruh, D.; Strobel, D.; Michiels, R.; Huber, D.; Brandel, A.; Madl, J.; Gavrilov, A.; Mihlan, M.; Daller, C. C.; Rog-Zielinska, E. A.; Römer, W.; Lämmermann, T.; Rohrbach, A.
Nat Commun 2022, 13 (1), 1758. https://doi.org/10.1038/s41467-022-29091-0

SARS-CoV-2 Infection of Lung Organoids Reveals Conserved Use of Tetraspanin-8 by Ancestral-, Delta-, and Omicron- Variants.
Hysenaj, L.; Little, S.; Kulhanek, K. R.; Magnen, M.; Bahl, K.; Gbenedio, O. M. G.; Prinz, M.; Rodriguez, L.; Andersen, C.; Rao, A. A.; Shen, A.; Lone, J. C.; Lupin Jimenez, L. C.; Bonser, L.; Serwas, N. K.; Mick, E.; Khalid, M. M.; Taha, T. Y.; Kumar, R.; Li, J. Z.; Ding, V. W.; Matsumoto, S.; Maishan, M.; Sreekumar, B.; Simoneau, C.; Nazarenko, I.; Tomlinson, M.; Khan, K.; Von Gottberg, A.; Sigal, A.; Looney, M. R.; Fragiadakis, G. K.; Jablons, D. M.; Langelier, C.; Matthay, M. A.; Krummel, M. F.; Erle, D. J.; Combes, A. J.; Sil, A.; Ott, M.; Kratz, J. R.; Roose, J. P.
SSRN Journal 2022. https://doi.org/10.2139/ssrn.4198511

Kidins220 Promotes Thymic iNKT Cell Development by Reducing TCR Signals, but Enhances TCR Signals in Splenic iNKT Cells.
Herr, L. A.; Fiala, G. J.; Schaffer, A.-M.; Raute, K.; Velasco Cárdenas, R. M.-H.; Hummel, J. F.; Ebert, K.; Tanriver, Y.; Minguet, S.; Schamel, W. W.
Immunology April 7, 2022. https://doi.org/10.1101/2022.04.05.487104

Photoaffinity Capture Compounds to Profile the Magic Spot Nucleotide Interactomes**.
Haas, T. M.; Laventie, B.; Lagies, S.; Harter, C.; Prucker, I.; Ritz, D.; Saleem‐Batcha, R.; Qiu, D.; Hüttel, W.; Andexer, J.; Kammerer, B.; Jenal, U.; Jessen, H. J.
Angew Chem Int Ed 2022, 61 (22), e202201731. https://doi.org/10.1002/anie.202201731

IRE1 and PERK Signaling Regulates Inflammatory Responses in a Murine Model of Contact Hypersensitivity.
Völkel, L.; Fluck, M.; Apostolova, P.; Zeiser, R.; Jakob, T.; Martin, S. F.; Esser, P. R.
Allergy 2022, 77 (3), 966–978. https://doi.org/10.1111/all.15024

Benchmarking of Cph1 Mutants and Dr BphP for Light‐Responsive Phytochrome‐Based Hydrogels with Reversibly Adjustable Mechanical Properties.
Emig, R.; Hoess, P.; Cai, H.; Kohl, P.; Peyronnet, R.; Weber, W.; Hörner, M.
Advanced Biology 2022, 6 (7), 2000337. https://doi.org/10.1002/adbi.202000337

3D Printed Solutions for Spheroid Engineering and Cancer Research
Butelmann, T.; Gu, Y.; Li, A.; Tribukait-Riemenschneider, F.; Hoffmann, J.; Molazem, A.; Jaeger, E.; Pellegrini, D.; Forget, A.; Shastri, V. P.
IJMS 2022, 23 (15), 8188. https://doi.org/10.3390/ijms23158188

2021

Liquid-Liquid Phase Separation of Light-Inducible Transcription Factors Increases Transcription Activation in Mammalian Cells and Mice.
Schneider, N.; Wieland, F.-G.; Kong, D.; Fischer, A. A. M.; Hörner, M.; Timmer, J.; Ye, H.; Weber, W.
Sci. Adv. 2021, 7 (1), eabd3568. https://doi.org/10.1126/sciadv.abd3568

Uncovering a Novel Function of the CCR4-NOT Complex in Phytochrome A-Mediated Light Signalling in Plants.
Schwenk, P.; Sheerin, D. J.; Ponnu, J.; Staudt, A.-M.; Lesch, K. L.; Lichtenberg, E.; Medzihradszky, K. F.; Hoecker, U.; Klement, E.; Viczián, A.; Hiltbrunner, A.
eLife 2021, 10, e63697. https://doi.org/10.7554/eLife.63697

Designed membrane protein heterodimers and control of their affinity by binding domain and membrane linker properties.
Lan C, Stulz A, Barthes NPF, Lauw S, Salavei P, Jung M, Heerklotz H, Ulbrich MH.
Nanoscale. 2021 Dec 16;13(48):20692-20702. doi: 10.1039/d1nr06574b. PMID: 34878479

Bacterial lectin BambL acts as a B cell superantigen.
Frensch M, Jäger C, Müller PF, Tadi? A, Wilhelm I, Wehrum S, Diedrich B, Fischer B, Meléndez AV, Dengjel J, Eibel H, Römer W.
Cell Mol Life Sci. 2021 Dec;78(24):8165-8186. doi: 10.1007/s00018-021-04009-z.

Cardiomyocyte-specific miR-100 overexpression preserves heart function under pressure overload in mice and diminishes fatty acid uptake as well as ROS production by direct suppression of Nox4 and CD36.
Smolka C, Schlösser D, Koentges C, Tarkhnishvili A, Gorka O, Pfeifer D, Bemtgen X, Asmussen A, Groß O, Diehl P, Moser M, Bode C, Bugger H, Grundmann S, Pankratz F.
FASEB J. 2021 Nov;35(11):e21956. doi: 10.1096/fj.202100829RR.

finDr: A web server for in silico D-peptide ligand identification.
Engel H, Guischard F, Krause F, Nandy J, Kaas P, Höfflin N, Köhn M, Kilb N, Voigt K, Wolf S, Aslan T, Baezner F, Hahne S, Ruckes C, Weygant J, Zinina A, Akmeriç EB, Antwi EB, Dombrovskij D, Franke P, Lesch KL, Vesper N, Weis D, Gensch N, Di Ventura B, Öztürk MA.
Synth Syst Biotechnol. 2021 Nov 23;6(4):402-413. doi: 10.1016/j.synbio.2021.11.004.

MiR-100 overexpression attenuates high fat diet induced weight gain, liver steatosis, hypertriglyceridemia and development of metabolic syndrome in mice.
Smolka C, Schlösser D, Hohnloser C, Bemtgen X, Jänich C, Schneider L, Martin J, Pfeifer D, Moser M, Hasselblatt P, Bode C, Grundmann S, Pankratz F.
Mol Med. 2021 Sep 6;27(1):101. doi: 10.1186/s10020-021-00364-6.

Impact of DJ-1 and Helix 8 on the Proteome and Degradome of Neuron-Like Cells.
Kern U, Fröhlich K, Bedacht J, Schmidt N, Biniossek ML, Gensch N, Baerenfaller K, Schilling O.
Cells. 2021 Feb 16;10(2):404. doi: 10.3390/cells10020404.

Yersinia Pseudotuberculosis Cytotoxic Necrotizing Factor Interacts with Glycosaminoglycans.
Kowarschik, S.; Schöllkopf, J.; Müller, T.; Tian, S.; Knerr, J.; Bakker, H.; Rein, S.; Dong, M.; Weber, S.; Grosse, R.; Schmidt, G.
The FASEB Journal 2021, 35 (7). https://doi.org/10.1096/fj.202001630R

Spatiotemporally Confined Red Light-Controlled Gene Delivery at Single-Cell Resolution Using Adeno-Associated Viral Vectors.
Hörner, M.; Jerez-Longres, C.; Hudek, A.; Hook, S.; Yousefi, O. S.; Schamel, W. W. A.; Hörner, C.; Zurbriggen, M. D.; Ye, H.; Wagner, H. J.; Weber, W.
Sci. Adv. 2021, 7 (25), eabf0797. https://doi.org/10.1126/sciadv.abf0797

Engineered Chimeric T Cell Receptor Fusion Construct (TRuC)-Expressing T Cells Prevent Translational Shutdown in SARS-CoV-2-Infected Cells.
Ciminski, K.; Yousefi, O. S.; Pathan-Chhatbar, S.; Saltukoglu, D.; Vesper, N.; Salavei, P.; Strietz, J.; Gensch, N.; Reth, M.; Schwemmle, M.; Schamel, W. W.
Bioengineering June 25, 2021. https://doi.org/10.1101/2021.06.25.449871

Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition.
Catalano, A.; Adlesic, M.; Kaltenbacher, T.; Klar, R. F. U.; Albers, J.; Seidel, P.; Brandt, L. P.; Hejhal, T.; Busenhart, P.; Röhner, N.; Zodel, K.; Fritsch, K.; Wild, P. J.; Duyster, J.; Fritsch, R.; Brummer, T.; Frew, I. J.
Cancers 2021, 13 (8), 1852. https://doi.org/10.3390/cancers13081852

The Gb3-Enriched CD59/Flotillin Plasma Membrane Domain Regulates Host Cell Invasion by Pseudomonas Aeruginosa.
Brandel, A.; Aigal, S.; Lagies, S.; Schlimpert, M.; Meléndez, A. V.; Xu, M.; Lehmann, A.; Hummel, D.; Fisch, D.; Madl, J.; Eierhoff, T.; Kammerer, B.; Römer, W.
Cell. Mol. Life Sci. 2021, 78 (7), 3637–3656. https://doi.org/10.1007/s00018-021-03766-1

2020

Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes.
Jumaa H, Caganova M, McAllister EJ, Hoenig L, He X, Saltukoglu D, Brenker K, Köhler M, Leben R, Hauser AE, Niesner R, Rajewsky K, Reth M, Jellusova J.
Life Sci Alliance. 2020 Apr 27;3(6):e202000700. doi: 10.26508/lsa.202000700.

Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A.
Hoermann B, Kokot T, Helm D, Heinzlmeir S, Chojnacki JE, Schubert T, Ludwig C, Berteotti A, Kurzawa N, Kuster B, Savitski MM, Köhn M.
Nat Commun. 2020 Jul 17;11(1):3583.doi: 10.1038/s41467-020-17334-x.

Optogenetic Tuning of Ligand Binding to The Human T Cell Receptor Using The Opto-Ligand-TCR System.
Yousefi, O. S.; Hörner, M.; Wess, M.; Idstein, V.; Weber, W.; Schamel, W.
BIO-PROTOCOL 2020, 10 (5). https://doi.org/10.21769/BioProtoc.3540

Glycosaminoglycans Are Specific Endosomal Receptors for Yersinia Pseudotuberculosis Cytotoxic Necrotizing Factor.
Kowarschik, S.; Schöllkopf, J.; Müller, T.; Tian, S.; Knerr, J.; Bakker, H.; Rein, S.; Dong, M.; Weber, S.; Grosse, R.; Schmidt, G.
Pharmacology and Toxicology May 18, 2020. https://doi.org/10.1101/2020.05.18.101790

2019

Comparison of different label-free imaging high-throughput biosensing systems for aptamer binding measurements using thrombin aptamers.
Rath C, Burger J, Norval L, Kraemer SD, Gensch N, van der Kooi A, Reinemann C, O’Sullivan C, Svobodova M, Roth G.
Anal Biochem. 2019 Oct 15;583:113323. doi: 10.1016/j.ab.2019.05.012. .

A Monoallelic Two-Hit Mechanism in PLCD1 Explains the Genetic Pathogenesis of Hereditary Trichilemmal Cyst Formation.
Hörer S, Marrakchi S, Radner FPW, Zolles G, Heinz L, Eichmann TO, Has C, Salavei P, Mahfoudh N, Turki H, Zimmer AD, Fischer J.
J Invest Dermatol. 2019 Oct;139(10):2154-2163.e5. doi: 10.1016/j.jid.2019.04.015.

Production of Phytochromes by High-Cell-Density E. coli Fermentation.
Hörner M, Gerhardt K, Salavei P, Hoess P, Härrer D, Kaiser J, Tabor JJ, Weber W.
ACS Synth Biol. 2019 Oct 18;8(10):2442-2450.doi: 10.1021/acssynbio.9b00267.

2018

Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells.
Baaske J, Gonschorek P, Engesser R, Dominguez-Monedero A, Raute K, Fischbach P, Müller K, Cachat E, Schamel WWA, Minguet S, Davies JA, Timmer J, Weber W, Zurbriggen MD.
Sci Rep. 2018 Oct 9;8(1):15024.

Multiplexed antibody detection from blood sera by immobilization of in vitro expressed antigens and label-free readout via imaging reflectometric interferometry (iRIf).
Bender J, Bognar S, Camagna M, Donauer JAM, Eble JW, Emig R, Fischer S, Jesser R, Keilholz L, Kokotek DMU, Neumann J, Nicklaus S, Oude Weernink RRQPT, Stühn LG, Wössner N, Krämer SD, Schwenk P, Gensch N, Roth G, Ulbrich MH.
Biosens Bioelectron. 2018 Sep 15;115:97-103.

Anti-CD3 Fab Fragments Enhance Tumor Killing by Human gamma delta T Cells Independent of Nck Recruitment to the gamma delta T Cell Antigen Receptor.
Juraske C, Wipa P, Morath A, Hidalgo JV, Hartl FA, Raute K, Oberg HH, Wesch D, Fisch P, Minguet S, Pongcharoen S, Schamel WW.
Front Immunol. 2018 Jul 9;9:1579.

Miniature scanning light-sheet illumination implemented in a conventional microscope.
Bhat Kashekodi A, Meinert T, Michiels R, Rohrbach A
Biomed Opt Express, 2018 Sep 1 Vol. 9, No. 9; 4263 – 4274

OptoBase: A web platform for molecular optogenetics.
Kolar K, Knobloch C, Stork H, Žnidaric M, Weber W.
ACS Synth Biol. 2018 Jul 20;7(7):1825-1828.

Synthetic Biology Makes Polymer Materials Count.
Beyer HM, Engesser R, Hörner M, Koschmieder J, Beyer P, Timmer J, Zurbriggen MD, Weber W.
Adv Mater. 2018 May;30(21):e1800472.

Lectin-mediated protocell crosslinking to mimic cell-cell junctions and adhesion.
Villringer S, Madl J, Sych T, Manner C, Imberty A, Römer W.
Sci Rep. 2018 Jan 31;8(1):1932.

A Web Platform for Molecular Optogenetics.
Kolar, K.; Knobloch, C.; Stork, H.; Žnidarič, M.; Weber, W. OptoBase:
ACS Synth. Biol. 2018, 7 (7), 1825–1828. https://doi.org/10.1021/acssynbio.8b00120

2017

PCH1 and PCHL promote photomorphogenesis in plants by controlling phytochrome B dark reversion.
Enderle B, Sheerin DJ, Paik I, Kathare PK, Schwenk P, Klose C, Ulbrich MH, Huq E, Hiltbrunner A.
Nat Commun. 2017 Dec 20;8(1):2221.

Disordered Conformation with Low Pii Helix in Phosphoproteins Orchestrates Biomimetic Apatite Formation.
Sarem M, Ludeke S, Thomann R, Salavei P, Zou Z, Habraken W, Masic A, and Shastri VP
Adv Mater. 2017 Sep;29(35).

Gene regulation during Drosophila eggshell patterning.
George Pyrowolakis, Ville Veikkolainen, Nir Yakoby, and Stanislav Y. Shvartsman
PNAS June 6, 2017 114 (23) 5808-5813

Mutations in SULT2B1 Cause Autosomal-Recessive Congenital Ichthyosis in Humans.
Lisa Heinz, Gwang-Jin Kim, Slaheddine Marrakchi, Julie Christiansen, Hamida Turki, Marc-Alexander Rauschendorf, Mark Lathrop, Ingrid Hausser, Andreas D. Zimmer, and Judith Fischer
Am J Hum Genet. 2017 Jun 1;100(6):926-939.

Sex-Specific Transcript Diversity in the Fly Head Is Established during Pupal Stages and Adulthood and Is Largely Independent of the Mating Process and the Germline.
Mohr C, Kleiner S, Blanchette M, Pyrowolakis G, Hartmann B.
Sex Dev. 2017;11(2):94-108.

Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition. Diedrich B, Rigbolt KT, Röring M, Herr R, Kaeser-Pebernard S, Gretzmeier C, Murphy RF, Brummer T, Dengjel J.
EMBO J. 2017 Mar 1;36(5):646-663.

Gb3-binding lectins as potential carriers for transcellular drug delivery.
Müller SK, Wilhelm I, Schubert T, Zittlau K, Imberty A, Madl J, Eierhoff T, Thuenauer R, Römer W.
Expert Opin Drug Deliv. 2017 Feb;14(2):141-153.

Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells.
Zahaf NI, Lang AE, Kaiser L, Fichter CD, Lassmann S, McCluskey A, Augspach A, Aktories K, Schmidt G.
Sci Rep. 2017 Jan 27;7:41252.

2016

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.
Keller B, Zaidman I, Yousefi OS, Hershkovitz D, Stein J, Unger S, Schachtrup K, Sigvardsson M, Kuperman AA, Shaag A, Schamel WW, Elpeleg O, Warnatz K, Stepensky P.
J Exp Med. 2016 Jun 27;213(7):1185-99.

Pentagone internalises glypicans to fine-tune multiple signalling pathways.
Norman M, Vuilleumier R, Springhorn A, Gawlik J, Pyrowolakis G.
Elife. 2016 Jun 8;5. pii: e13301.

Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning.
Paensuwan P, Hartl FA, Yousefi OS, Ngoenkam J, Wipa P, Beck-Garcia E, Dopfer EP, Khamsri B, Sanguansermsri D, Minguet S, Schamel WW, Pongcharoen S.
J Immunol. 2016 Jan 1;196(1):448-58.

Signalling to the nucleus under the control of light and small molecules.
Juillot S, Beyer HM, Madl J, Weber W, Zurbriggen MD, Römer W.
Mol Biosyst. 2016 Feb;12(2):345-9.

2015

Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.
Fiala GJ, Janowska I, Prutek F, Hobeika E, Satapathy A, Sprenger A, Plum T, Seidl M, Dengjel J, Reth M, Cesca F, Brummer T, Minguet S, Schamel WW.
J Exp Med. 2015 Sep 21;212(10):1693-708.

Red Light-Regulated Reversible Nuclear Localization of Proteins in Mammalian Cells and Zebrafish.
Beyer HM, Juillot S, Herbst K, Samodelov SL, Müller K, Schamel WW, Römer W, Schäfer E, Nagy F, Strähle U, Weber W, Zurbriggen MD.
ACS Synth Biol. 2015 Sep 18;4(9):951-8.

AQUA Cloning: A Versatile and Simple Enzyme-Free Cloning Approach.
Beyer HM, Gonschorek P, Samodelov SL, Meier M, Weber W, Zurbriggen MD.
PLoS One. 2015 Sep 11;10(9):e0137652.

2014

B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk.
Kläsener K, Maity PC, Hobeika E, Yang J, Reth M.
Elife. 2014 Jun 24;3:e02069.

The CD3 conformational change in the gamma delta T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.
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