We use Drosophila melanogaster as a model organism to address basic questions in the regulation of intercellular signaling. We are particularly interested in morphogen signaling elicited by Drosophila BMPs and use a combination of approaches to understand how gradients of signaling activity are established and maintained and how cells within the morphogen-field sense and interpret graded signaling.
- Vigano, M. A., Ell, C. M., Kustermann, M. M., Aguilar, G., Matsuda, S., Zhao, N., … & Pyrowolakis, G. (2021). Protein manipulation using single copies of short peptide tags in cultured cells and in Drosophila melanogaster. Development, 148(6), dev191700.
- Vuilleumier, R., Springhorn, A., Patterson, L., Koidl, S., Hammerschmidt, M., Affolter, M., & Pyrowolakis, G. (2010). Control of Dpp morphogen signalling by a secreted feedback regulator. Nature cell biology, 12(6), 611-617.
- Pyrowolakis, G., Hartmann, B., Müller, B., Basler, K., & Affolter, M. (2004). A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Developmental cell, 7(2), 229-240.
What I am looking for in a prospective Rising Star
The prospective candidate in the FRSA should share scientific and research interests with us. Ideally, the candidate has a proven record of work experience in our field of research – or in a research field with strong connections to our research foci.
Ideally, the stay of the candidate in my lab should serve as a platform for one of the following:
- Bilateral exchange of ideas and/or new technologies to tackle common scientific questions
- Laying the foundation for future collaboration
- Setting the basis for joint funding applications (for example by generating preliminary data and testing new ideas)